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Unexplained shoulder pain could signal dangerous health condition, doctor warns

  • April 06, 2026
  • Health Care

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Various types of shoulder pain

“Most shoulder pain is caused by far more ordinary things, like muscle strain, arthritis, tendon problems or poor posture,” Ashamalla said.

Typical orthopedic shoulder pain usually occurs after an injury, overuse, sleeping awkwardly, lifting something heavy or repetitive motion, according to the doctor.

“It tends to worsen with certain arm movements, and the shoulder may feel tender, stiff, weak or have a limited range of motion,” he said. “By contrast, referred pain from the liver often does not behave like a shoulder problem.”

Mature Caucasian man sitting on sofa holding his painful shoulder

Published case reports have shown that shoulder pain can be a symptom of hepatocellular carcinoma (HCC), the most common type of primary liver cancer. (iStock)

The doctor listed the following clues that may indicate referred shoulder pain linked to liver cancer. 

  • Pain on the right side, often near the top of the shoulder or around the right shoulder blade
  • Pain that’s not clearly triggered by moving the arm
  • Pain when the shoulder exam itself seems relatively normal
  • Pain that feels more like a deep, dull ache than a sharp mechanical pain
  • Pain that keeps going despite rest or routine treatment
  • Pain that comes with other symptoms like weight loss, poor appetite, nausea, fatigue, abdominal fullness, abdominal swelling or jaundice (yellowing of the skin and eyes)

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“That said, these are warning signs, not proof. There’s no single pain pattern that automatically means cancer,” Ashamalla emphasized. 

“What matters most is when the pain does not fit the usual orthopedic pattern or is accompanied by other concerning symptoms.”

Other liver cancer symptoms

One of the challenges with liver cancer is that it often causes no early symptoms at all, or only very vague ones, according to Ashamalla.

“Liver cancer often does not present with one obvious, dramatic symptom,” he said. “Instead, it may show up as a cluster of vague changes that are easy to brush off one by one.”

Doctor displaying a 3D model of a liver in a clinic.

One of the challenges with liver cancer is that it often causes no early symptoms at all, or only very vague ones, according to the doctor. (iStock)

Ashamalla shared the following liver cancer symptoms that can be subtle and easy to overlook.

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  • Feelings of fullness after only a small amount of food
  • Loss of appetite and lack of desire to eat, especially when it’s persistent and unexplained
  • Unintentional weight loss
  • Persistent fatigue or weakness that doesn’t seem to improve
  • Upper abdominal discomfort, pressure or heaviness, or a sense of fullness under the right ribs
  • Abdominal swelling, which can happen if fluid builds up in the abdomen
  • Jaundice (yellowing of the skin or eyes), which can be subtle at first
  • Dark urine or pale stools, indicating that the liver or bile system is not functioning normally
  • Itching, even without a visible rash
  • Low-grade fevers or flu-like feelings without a clear infection

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When to see a doctor

Ashamalla stressed that people shouldn’t be frightened by every ache or pain.

“Shoulder pain is extremely common, and in most cases the cause is benign,” he said. “Don’t panic about ordinary shoulder pain, but don’t ignore it if it’s persistent, unexplained, or comes with other red-flag symptoms.”

Woman undergoing medical exam with doctor in clinical setting

For those who already have liver disease or risk factors for liver cancer, such as cirrhosis or chronic hepatitis, unexplained symptoms may warrant a greater concern. (iStock)

For those who already have liver disease or risk factors for liver cancer, such as cirrhosis or chronic hepatitis, unexplained symptoms may warrant a greater concern.

People should seek medical attention if their pain meets any of the following criteria, according to the doctor.

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  • Lasts more than a few weeks
  • Has no clear injury or trigger
  • Doesn’t improve with rest or standard treatment
  • Is present even when the shoulder is not being used
  • Is worse at night or when at rest
  • Continues even when the shoulder itself seems normal
  • Is accompanied by other liver cancer symptoms

Melissa Rudy is senior health editor and a member of the lifestyle team at Fox News Digital. Story tips can be sent to melissa.rudy@fox.com.

Article source: https://www.foxnews.com/health/unexplained-shoulder-pain-could-signal-dangerous-health-condition-doctor-warns

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