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Study reveals how rapidly weight comes back after quitting obesity medications

  • January 20, 2026
  • Health Care

Weight-loss journeys can cause social strains for GLP-1 patients, doctor says Video

“Such practices not only help prevent excess weight gain, but can also lead to numerous health benefits that go beyond weight control.”

Why patients quit

Recent reports have disclosed that more older Americans are deciding to quit their GLP-1s for a variety of reasons.

Additionally, a 2025 study published in JAMA — which included more than 125,000 overweight or obese people — found that nearly 47% of those with type 2 diabetes and 65% of those without diabetes stopped taking their prescribed GLP-1s within a year of starting them.

person stands on scale holding GLP1 injection

Common GLP-1 side effects include nausea, vomiting, diarrhea, constipation, bloating, headaches, fatigue and hair thinning, according to experts. (iStock)

Users and experts have claimed that cost, muscle loss, dehydration and side effects are the most common reasons weight-loss drugs are discontinued.

Side effects often include nausea, vomiting, diarrhea, constipation, bloating, headaches, fatigue and hair thinning, according to experts.

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In a previous interview with Fox News Digital, Dr. Sue Decotiis, a medical weight-loss doctor in New York City, noted that older patients are especially more sensitive to gastrointestinal side effects.

“Careful monitoring by a physician who is knowledgeable in the area of medical weight loss is imperative,” she said.

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“Often, using a customized dosing plan helps the patient avoid undue side effects and helps them burn more fat, which is the mechanism by which GLP drugs work long-term and systemically,” she went on. “For certain patients, a high-quality compounded GLP-1 can achieve tailored dosing.”

“Many of the patients who quit their GLP-1 drugs could have stayed on them with the right personalized care.”

Article source: https://www.foxnews.com/health/study-reveals-how-rapidly-weight-comes-back-after-quitting-obesity-medications

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