After investigating why APOE4 might lead to this change, researchers considered that Wnt signalling is governed by two proteins: beta-catenin, which boosts its activity, and glycogen synthase kinase 3 beta (GSK3b), which suppresses it.
Article source: https://www.huffingtonpost.co.uk/entry/apoe4-dementia-gene-fat-droplets_uk_6ada1027e4b02def986b1702