Needle-free diabetes management could be on the horizon, study suggests
The result was a rapid and significant drop in blood glucose, as well as a sustained (longer-term) decrease. The mice’s blood sugar was reduced to near-normal levels.
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When DNP-V was attached directly to insulin, the results showed enhanced absorption in the intestines and a similar glucose-lowering effect, the researchers noted.
The treatment was effective in different diabetes models, significantly reducing blood sugar spikes after meals with just one dose per day.
The study was done in mice, which leaves uncertainty if the treatment will translate to humans. (iStock)
The findings suggest that DNP peptides could serve as flexible, adaptable platforms for delivering large-molecule drugs by mouth, the authors concluded in the study abstract.
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“This technology can simply and effectively convert injectable biopharmaceuticals into orally administrable forms, offering a promising path to practical, patient-friendly oral therapies,” they wrote.
Although the researchers are optimistic about the findings translating to larger therapeutic models, they noted that the results in mice do not guarantee the same outcome in humans, and that more research is needed.
For diabetics, insulin is typically administered via injection to regulate blood sugar levels. (iStock)
Dr. Marc Siegel commented on this development, noting that oral insulin could make a big difference in healthcare.
“Insulin use, especially in type 1 diabetes, is sometimes difficult to regulate by injection,” Siegel, who was not involved in the study, told Fox News Digital. “Oral use would have major advantages.”
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He added, “This is very promising provided that it works in humans, which is a big ‘if.'”
Fox News Digital reached out to the study authors for comment.
Angelica Stabile is a lifestyle reporter for Fox News Digital.
Article source: https://www.foxnews.com/health/needle-free-diabetes-management-could-horizon-study-suggests